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Begusova, M ; Gillard, N ; Sy, D ; Castaing, B ; Charlier, M ; Spotheim-Maurizot, M

Radiolysis of DNA-protein complexes

Radiation Physics and Chemistry 72 (2-3) 265-270

par Administrateur - publié le

Abstract :

We discuss here modifications of DNA and protein radiolysis due to the interaction of the-se two partners in specific complexes. Experimental patterns of frank strand breaks (FSB) and alkali revealed breaks (ARB) obtained for DNNA lac operator bound to the lac repressor and for a DNA containing an abasic site analog bound to the formamidopyrimidine-DNA glycosylase are reported. Experimental data are compared to predicted damage distribution obtained using the theoretical model RADACK. (C) 2004 Elsevier Ltd. All rights reserved.