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Grosse, S ; Aron, Y ; Thevenot, G ; Francois, D ; Monsigny, M ; Fajac, I

Potocytosis and cellular exit of complexes as cellular pathways for gene delivery by polycations

Journal of Gene Medicine 7 (10) 1275-1286

par Administrateur - publié le , mis à jour le

Abstract :

Background : Although polycations are among the most efficient nonviral vectors for gene transfer, the gene expression they allow is still too low for in vivo applications. To engineer more potent polycationic vectors, the factors governing the intracellular trafficking of a plasmid complexed with current polycations need to be identified.