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Accueil > Publications > Recherche par années > Années 2000 > 2005

Vallee, B ; Riezman, H

Lip1p : a novel subunit of acyl-CoA ceramide synthase

Embo Journal 24 (4) 730-741

par Administrateur - publié le

Abstract :

Ceramide plays a crucial role as a basic building block of sphingolipids, but also as a signalling molecule mediating the fate of the cell. Although Lac1p and Lag1p have been shown recently to be involved in acyl- CoA- dependent ceramide synthesis, ceramide synthase is still poorly characterized. In this study, we expressed tagged versions of Lac1p and Lag1p and purified them to near homogeneity.