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Rautureau, G ; Jouvensal, L ; Decoville, M ; Locker, D ; Vovelle, FO ; Schoentgen, FO

Cloning, high yield over-expression, purification, and characterization of CG18594, a new PEBP/RKIP family member from Drosophila melanogaster

Protein Expression and Purification 48 (1) 90-97

par Administrateur - publié le , mis à jour le

Abstract :

The phosphatidylethanolamine-binding protein (PEBP) family is widely distributed in various species, from bacteria to mammals. These proteins seem to modulate important cell mechanisms : they control heterotrimeric G-proteins, inhibit the MAP-kinase and NF kappa B signaling pathways, and also serine proteases (thrombin, neuropsin, and chymotrypsin). In order to establish structure-function relationships for this family of proteins, our study focuses on PEBPs expressed within a single organism : Drosophila melanogaster, which constitutes a model system that lends itself well to establishing links between genes’ expression and the corresponding proteins’ functions, and to studying physiological mechanisms such as development.