Salvaing, J ; Decoville, M ; Mouchel-Vielh, E ; Bussiere, M ; Daulny, A ; Boldyreva, L ; Zhimulev, I ; Locker, D ; Peronnet, F
Bmc Biology 4 Art No. 9
publié le , mis à jour le
Background : Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ( ME). Our previous work has shown that corto, which codes for a chromodomain protein, and dsp1, which codes for an HMGB protein, belong to a class of genes called the Enhancers of trithorax and Polycomb (ETP) that interact with both PcG and trxG. Moreover, dsp1 interacts with the Hox gene Scr, the DSP1 protein is present on a Scr ME in S2 cells but not in embryos.