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Salvaing, J ; Decoville, M ; Mouchel-Vielh, E ; Bussiere, M ; Daulny, A ; Boldyreva, L ; Zhimulev, I ; Locker, D ; Peronnet, F

Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene : understanding the role of Enhancers of trithorax and Polycomb

Bmc Biology 4 Art No. 9

par Administrateur - publié le , mis à jour le

Abstract :

Background : Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ( ME). Our previous work has shown that corto, which codes for a chromodomain protein, and dsp1, which codes for an HMGB protein, belong to a class of genes called the Enhancers of trithorax and Polycomb (ETP) that interact with both PcG and trxG. Moreover, dsp1 interacts with the Hox gene Scr, the DSP1 protein is present on a Scr ME in S2 cells but not in embryos.