Cremer, GA ; Bureaud, N ; Piller, V ; Kunz, H ; Piller, F ; Delmas, AF
Chemmedchem 1 (9) 965-968
publié le , mis à jour le
The glycopeptide construct shown was synthesized using a convergent strategy based on oxime chemical ligation. It is composed of a universal T-helper and three tumor-related epitopes from the human mucin MUC1, an non-glycosylated repeat unit, and two units glycosylated with the Tn and TF epitopes, respectively. In association with a mild adjuvant suitable for human therapy, this construct elicited a strong specific immune response in mice, directed against natural tumor-associated structures.