Accueil > Publications > Recherche par années > Années 2000 > 2006

Aller, P ; Garnier, N ; Genest, M

Transmembrane helix packing of ErbB/Neu receptor in membrane environment : A molecular dynamics study

Journal of Biomolecular Structure & Dynamics 24 (3) 209-228

par Administrateur - publié le , mis à jour le

Abstract :

Dimerization or oligomerization of the ErbB/Neu receptors are necessary but not sufficient for initiation of receptor signaling. The two intracellular domains must be properly oriented for the juxtaposition of the kinase domains allowing trans-phosphorylation. This suggests that the transmembrane (TM) domain acts as a guide for defining the proper orientation of the intracellular domains. Two structural models, with the two helices either in left-handed or in right-handed coiling have been proposed as the TM domain structure of the active receptor.