Accueil > Publications > Recherche par années > Années 2000 > 2006

Hinsen, K

Comment on : "Energy landscape of a small peptide revealed by dihedral angle principal component analysis"

Proteins-Structure Function and Bioinformatics 64 (3) 795-797

par Administrateur - publié le

Abstract :

The dihedral angle principal component analysis method published recently by Mu, Nguyen, and Stock, is shown to produce distortions of the free energy landscape due to the neglect of constraints in the coordinates. It is further shown that these distortions can create artificial minima and energy barriers. The rugged energy landscape that the authors find for a small peptide chain might thus be an artifact of their method.