Partenaires

CNRS


Rechercher


Accueil > Publications > Recherche par années > Années 2000 > 2006

Livramento, JB ; Weidensteiner, C ; Prata, MIM ; Allegrini, PR ; Geraldes, CFGC ; Helm, L ; Kneuer, R ; Merbach, AE ; Santos, AC ; Schmidt, P ; Tóth, E

First in vivo MRI assessment of a self-assembled metallostar compound endowed with a remarkable high field relaxivity

Contrast Media & Molecular Imaging 1 (1) 30-40

par Administrateur - publié le

Abstract :

[Fe[Gd(2)bpy(DTTA)(2)(H2O)(4)](3)}(4-) is a self-assembled, metallostar-structured potential MRI contrast agent, with six efficiently relaxing Gd3+ centres confined into a small molecular space. its proton relaxivity is particularly remarkable at very high magnetic fields (r(1) = 15.8 mM(-1) s(-1) at 200 MHz, 37 degrees C, in H2O). Here we report the first in vivo MRI feasibility study, complemented with dynamic gamma scintigaphic imaging and biodistribution experiments using the Sm-153-enriched compound. Comparative MRI studies have been performed at 4.7 T in mice with the metallostar and the small molecular weight contrast agent gadolinium(III)-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetraacetate ([Gd(DOTA)(H2O)](-) = GdDOTA).