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Lebdušková, P ; Sour, A ; Helm, L ; Tóth, E ; Kotek, J ; Lukeš, I ; Merbach, AE

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer : an 17O and 1H relaxometric study of its Gd(III) complex

Dalton Transactions 3399-3406

par Administrateur - publié le

Abstract :

A DTPA-based chelate containing one phosphinate group was conjugated to a generation 5 polyamidoamine (PAMAM) dendrimer via a benzylthiourea linkage. The Gd(III) complex of this novel conjugate has potential as a contrast agent for magnetic resonance imaging (MRI). The chelates bind Gd3+ via three nitrogen atoms, four carboxylates and one phosphinate oxygen, and one water molecule completes the inner coordination sphere.