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Mennesson, E ; Erbacher, P ; Kuzak, M ; Kieda, C ; Midoux, P ; Pichon, C

DNA/cationic polymer complex attachment on a human vascular endothelial cell monolayer exposed to a steady laminar flow

Journal of Controlled Release 114 (3) 389-397

par Administrateur - publié le

Abstract :

This study evaluated for the first time the binding of pDNA/polymer complexes (polyplexes) on a human lung microvascular endothelial cell (HLMEC) monolayer under flow conditions. A slide of a HLMEC monolayer was mounted on a parallel flow chamber connected to an open flow system from a reservoir containing fluorescent polyplexes to a syringe.