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Was, H ; Cichon, T ; Smolarczyk, R ; Rudnicka, D ; Stopa, M ; Chevalier, C ; Leger, JJ ; Lackowska, B ; Grochot, A ; Bojkowska, K ; Ratajska, A ; Kieda, C ; Szala, S ; Dulak, J ; Jozkowicz, A

Overexpression of heme oxygenase-1 in murine melanoma - Increased proliferation and viability of tumor cells, decreased survival of mice

American Journal of Pathology 169 (6) 2181-2198

par Administrateur - publié le

Abstract :

Heme oxygenase-1 (HO-1), a cytoprotective enzyme, can be induced in tumors in response to anti-cancer therapies. We investigated the role of HO-1 in B16(F10), S91, and Sk-mel188 melanoma cells. Overexpression of HO-1 after transduction with adenoviral vectors increased cell proliferation, resistance to oxidative stress generated by H2O2, and angiogenic potential as determined by induction of endothelial cell divisions. Likewise, cells stably transfected with HO-1 cDNA (B16-HO-1) showed higher proliferation, stress resistance, and angiogenic activity than the wild-type line (B16-WT).