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Grosse, S ; Thevenot, G ; Monsigny, M ; Fajac, I

Which mechanism for nuclear import of plasmid DNA complexed with polyethylenimine derivatives ?

Journal of Gene Medicine 8 (7) 845-851

par Administrateur - publié le , mis à jour le

Abstract :

Background : To investigate the nuclear import mechanism of plasmid/polyethylenimine (PEI) derivative complexes and the putative nuclear targeting of therapeutic genes by the use of oligosaccharides, we have studied the nuclear import of plasmid DNA complexed either with PEI or with lactosylated PEI (Lac-PEI) in cystic fibrosis human airway epithelial cells (Sigma CFTE290-cells).