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Schoehn, G ; Vellieux, FMD ; Dura, MA ; Receveur-Brechot, V ; Fabry, CMS ; Ruigrok, RWH ; Ebel, C ; Roussel, A ; Franzetti, B

An archaeal peptidase assembles into two different quaternary structures - A tetrahedron and a giant octahedron

Journal of Biological Chemistry 281 (47) 36327-36337

par Administrateur - publié le

Abstract :

Cellular proteolysis involves large oligomeric peptidases that play key roles in the regulation of many cellular processes. The cobalt-activated peptidase TET1 from the hyperthermophilic Archaea Pyrococcus horikoshii (PhTET1) was found to assemble as a 12-subunit tetrahedron and as a 24-subunit octahedral particle. Both quaternary structures were solved by combining x-ray crystallography and cryoelectron microscopy data.