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Broggi, J ; Joubert, N ; Aucagne, V ; Berteina-Raboin, S ; Diez-Gonzalez, S ; Nolan, S ; Topalis, D ; Deville-Bonne, D ; Balzarini, J ; Neyts, J ; Andrei, G ; Snoeck, R ; Agrofoglio, LA

Alkyne-azide click chemistry mediated carbanucleosides synthesis

Nucleosides Nucleotides & Nucleic Acids 26 1391-1394

par Administrateur - publié le

Abstract :

Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4’,4’-dihydroxymethyl-3’-deoxycarbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.