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Broggi, J ; Joubert, N ; Aucagne, V ; Zevaco, T ; Berteina-Raboin, S ; Nolan, SR ; Agrofoglio, LA

Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides

Nucleosides Nucleotides & Nucleic Acids 26 779-783

par Administrateur - publié le

Abstract :

We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis(acelonitrile)copper hexafluorophosphate ([Cu(CH3CN4]PF6), the imidazoline(mesythyl)copper bromide (Imes)CuBr, and the copper/copper sulfate Cu(0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method.