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Bertrand, M. ; Chabin, A. ; Brack, A. & Westall, F.

Separation of amino acid enantiomers via chiral derivatization and non chiral column by gas chromatography

Journal of Chromatography A 1180 (1-2), 131-137.

par Administrateur - publié le , mis à jour le

Abstract :

Two GC-MS methods for the enantioselective separation of the 20 proteinogenic amino acids are compared. Ethyl chloroformate and 2-chloropropanol were used to derivatize amino acid enantiomers. The diastereomers formed were separated on a non-chiral column by capillary gas chromatography. The separation performances were compared to those obtained when using non-chiral derivatization on a chiral column. (c) 2007 Elsevier B.V. All rights reserved.