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Franchi, J ; Marteau, C ; Crola da Silva, C ; Mitterrand, M ; Andre, P ; Kieda, C

Cell model of inflammation

Bioscience Representatives 28 (1) 23-32

par Administrateur - publié le

Abstract :

Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through the selective barrier of the vascular ECs (endothelial cells). In the present study, we describe an in vitro model which takes into account the various steps of human skin inflammation, from keratinocyte activation to the adhesion of leucocytes to dermal capillary ECs.