Accueil > Publications > Recherche par années > Années 1990 > 1997

Gomez, JP ; Morel, N

Changes in the potassium currents of rat aortic smooth muscle cells during postnatal development

Vascular Research 34(S1) 057

par Administrateur - publié le

Abstract :

This study was designed to investigate the role and regulation of arterial K+ channels during postnatal development. Rat thoracic aortic segments were suspended for isometric tension and resting membrane potential (RMP) recording. Contraction in response to 4-aminopyridine (4-AP) was similar in 4-, 8- and 12-week-old rats but was higher in 1-day-old rats. Contraction in response to tetraethylammonium (TEA) increased after 4 weeks. TEA increased the contractions evoked by noradrenaline in the aorta from 8- and 12-week-old rats but not from 1-day- and 4-week-old rats. RMP did not change during development. Patch-clamp studies of freshly isolated smooth muscle cells from the same aortas bathed in Ca2+-free medium showed a voltage-dependent Kf current (IK) sensitive to 4-AP.