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Agrofoglio, LA ; Jacquinet, JC ; Lancelot, G

A multigram, stereoselective synthesis of D-[C-13(5)]ribose from D-[C-13(6)]glucose and its conversion into [C-13(5)]nucleosides

Tetrahedron Letters 38 (8) 1411-1412

par Administrateur - publié le

Abstract :

The preparation of C-13-labeled ribonucleosides starting from D-[C-13(6)]glucose in 45% overall yield is described. The key of this short synthetic way is the dehomologation of di-O-isopropylidene hexofuranose 2 with periodic acid and NaBH4 that afforded stereoselectively the labeled ribofuranose derivative 3 in high yield. (C) 1997 Elsevier Science Ltd.