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Accueil > Publications > Recherche par années > Années 2000 > 2007

Bisseret, P., Thielges, S., Bourg, S., Miethke, M., Marahiel, M.A. and Eustache, J.

Synthesis of a 2-indolylphosphonamide derivative with inhibitory activity against yersiniabactin biosynthesis

Tetrahedron Letters 48, 6080-6083

par Frapart - publié le , mis à jour le

Abstract :

We report the synthesis of an adenosyl-derived indolylphosphonamide analogue of salicyladenosylmonophosphate involved in the plague and tuberculosis siderophore biosyntheses. The compound proved to be a potent inhibitor of the Yersinia pestis salicylate adenylation domain YbtE catalyzing the initial step of yersiniabactin biosynthesis.