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Berchel, M. ; Haelters, J. P. ; Couthon-Gourves, H. ; Deschamps, L. ; Midoux, P. ; Lehn, P. ; Jaffres, P. A.

Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry

European Journal of Organic Chemistry 2011 (31) 6294-6303

par Frapart - publié le , mis à jour le

Abstract :

The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.