Berchel, M. ; Haelters, J. P. ; Couthon-Gourves, H. ; Deschamps, L. ; Midoux, P. ; Lehn, P. ; Jaffres, P. A.
European Journal of Organic Chemistry 2011 (31) 6294-6303
publié le , mis à jour le
The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.