Bertrand, E. ; Goncalves, C. ; Billiet, L. ; Gomez, J. P. ; Pichon, C. ; Cheradame, H. ; Midoux, P. and Guégan, P
Chem. Commun. 47 (46) 12547-12549
A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.