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Bertrand, E. ; Goncalves, C. ; Billiet, L. ; Gomez, J. P. ; Pichon, C. ; Cheradame, H. ; Midoux, P. and Guégan, P

Histidinylated linear PEI : a new efficient non-toxic polymer for gene transfer

Chem. Commun. 47 (46) 12547-12549

par Frapart - publié le

Abstract :

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.