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Grosse, S., Pillard, C., Massip, S., Léger, J.M., Jarry, C., Bourg, S., Bernard, P. and Guillaumet, G.

Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles

Chemistry A European Journal, 18 (47) 14943-14947

par Frapart - publié le , mis à jour le

Abstract :

Highly regioselective : An efficient synthesis of the imidazo[1,2-b]pyrazole core has been developed, and the first regioselective palladium-catalyzed direct arylation of the C-3 position is described (see scheme). Good to excellent yields were obtained for a wide range of aryl partners with electron-rich and electron-poor substituents. This methodology allows rapid access to a large variety of imidazo[1,2-b]pyrazole products and could open the way to the design of new biologically active compounds.