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Berchel M., Le Corre S., Le Gall T., Couthon-Gourvès H., Haelters J.P., Midoux P., Montier T., Lehn P. and Jaffrès P.A.

Trimethylarsonium-Based Cationic Phospholipids for Gene Delivery

Phosphorus, Sulfur, and Silicon and the Related Elements (2013) 188 (1-2) 91-94 - doi : 10.1080/10426507.2012.741161

par Frapart - publié le

Abstract :

Lipophosphoramide-based cationic lipids are a class of synthetic vectors used for gene delivery that can be produced in multigram scale. The use of trimethylarsonium moiety as a cationic polar head was beneficial to produce efficient gene delivery vectors for in vivo applications. Moreover, this type of cationic lipid can also exhibit some bactericidal effects.