Lefoix M., Mathis G., Kleinmann T., Truffert J.-C. and Asseline U.
The Journal of organic chemistry. 79 (7) 3221-3227 - doi : 10.1021/jo5000253
publié le , mis à jour le
The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA(PT)), designed to form two hydrogen bonds with a complementary dT residue, is reported. Oligonucleotides including this dA nucleoside analogue possess base-pairing properties similar to those of the parent oligonucleotide. This dA nucleoside analogue is more resistant to acid-catalyzed hydrolysis than dA.