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Lefoix M., Mathis G., Kleinmann T., Truffert J.-C. and Asseline U.

Pyrazolo 1,5-a -1,3,5-triazine C-Nucleoside as Deoxyadenosine Analogue : Synthesis, Pairing, and Resistance to Hydrolysis

The Journal of organic chemistry. 79 (7) 3221-3227 - doi : 10.1021/jo5000253

par Frapart - publié le , mis à jour le

Abstract :

The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA(PT)), designed to form two hydrogen bonds with a complementary dT residue, is reported. Oligonucleotides including this dA nucleoside analogue possess base-pairing properties similar to those of the parent oligonucleotide. This dA nucleoside analogue is more resistant to acid-catalyzed hydrolysis than dA.