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Bonnet, C.S., Caillé, F., Pallier, A., Morfin, J.-F., Petoud, S., Suzenet, F., Tóth, É.

Mechanistic Studies of Gd3+-Based MRI Contrast Agents for Zn2+ Detection : Towards Rational Design

Chemistry – A European Journal (2014) 20 (35) 10959-10969 - doi : 10.1002/chem.201403043

par Frapart - publié le , mis à jour le

Abstract :

A series of novel pyridine-based Gd3+ complexes have been prepared and studied as potential MRI contrast agents for Zn2+ detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn2+ binding in terms of variations of the rotational motion.