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Bonnet, C. S. ; Caille, F. ; Pallier, A. ; Morfin, J. F. ; Petoud, S. ; Suzenet, F. and Toth, E.

Mechanistic studies of Gd3+-based MRI contrast agents for Zn2+ detection : towards rational design

Chemistry (2014) - doi : 10.1002/chem.201403043

par Frapart - publié le

Abstract :

A series of novel pyridine-based Gd(3+) complexes have been prepared and studied as potential MRI contrast agents for Zn(2+) detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn(2+) binding in terms of variations of the rotational motion.