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Accueil > Publications > Recherche par années > Années 2010 > 2016

He, J. Bonnet, C. S. Eliseeva, S. V. Lacerda, S. Chauvin, T. Retailleau, P. Szeremeta, F. Badet, B. Petoud, S. Tóth, E. and Durand, P.

Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities : Visible/Near-Infrared Luminescence, PARACEST-, and T-MRI

Journal of the American Chemical Society (2016) 138 (9) 2913-2916 - doi : 10.1021/jacs.5b12084

par Frapart - publié le , mis à jour le

Abstract :

We report first prototypes of responsive lanthanide(III) complexes that can be monitored independently in three complementary imaging modalities. Through the appropriate choice of lanthanide(III) cations, the same reactive ligand can be used to form complexes providing detection by (i) visible (Tb3+) and near-infrared (Yb3+) luminescence, (ii) PARACEST- (Tb3+, Yb3+), or (iii) T1-weighted (Gd3+) MRI. The use of lanthanide(III) ions of different natures for these imaging modalities induces only a minor change in the structure of complexes that are therefore expected to have a single biodistribution and cytotoxicity.