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Barbeau J., Lemiègre L., Quelen A., Malard V., Gao H., Gonçalves C., Berchel M., Jaffrès P.-A., Pichon C., Midoux P. and Benvegnu T.

Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

Carbohydrate Research (2016) 435, 142-148 - doi : 10.1016/j.carres.2016.10.003

par Frapart - publié le , mis à jour le

Abstract :

An archaeal diether lipid possessing a tri-antenna of α-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively.