Terrier V. P., Delmas A. F. and Aucagne V.
Organic and Biomolecular Chemistry (2017) 15 (2) 316-319
publié le , mis à jour le
We herein introduce a straightforward synthetic route to cysteine-containing cyclic peptides based on the intramolecular native chemical ligation of in situ generated thioesters. Key precursors are N-Hnb-Cys crypto-thioesters, easily synthesized by Fmoc-based SPPS. The strategy is applied to a representative range of naturally occurring cyclic disulfide-rich peptide sequences.