Partenaires

CNRS


Rechercher


Accueil > Publications > Recherche par années > Années 2010 > 2017

Hashami, Z., Martins, A. F., Funk, A. M., Jordan, V. C., Petoud, S., Eliseeva, S. V. and Kovacs, Z.

Lanthanide DO3A-Tropone Complexes : Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

European Journal of Inorganic Chemistry (2017) 2017 (43) 4965-4968

par Frapart - publié le

Abstract :

In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (1). Ln3+ complexes of 1 have one inner sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange rate by a factor of 3 compared to GdDOTA. In addition, Nd1 and Yb1 complexes exhibit significant NIR emission in aqueous solutions indicating that the tropone unit is an efficient sensitizer for these Ln3+-ions. Therefore, this new ligand is a promising platform for the design of Ln3+ based dual MR/optical imaging probes. Lanthanide DO3A-Tropone Complexes : Efficient Dual MR/NIR Imaging Probes in Aqueous Medium. Available from :

Voir en ligne : 10.1002/ejic.201701003