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Mayer F., Krishnan S. T., Schuehle D. T., Eliseeva S. V., Petoud S., Toth E. and Djanashvili K.

Luminescence Properties of Self-Aggregating Tb-III-DOTA-Functionalized Calix 4 arenes.

Frontiers in Chemistry, (2018) 6.

par Frapart - publié le

Abstract :

Self-aggregating calix[4] arenes carrying four DOTA ligands on the upper rim for stable complexation of paramagnetic Gd-III-ions have already been proposed as MRI probes. In this work, we investigate the luminescence properties of Tb-III-DOTA-calix[4] arene-4OPr containing four propyl-groups and compare them with those of the analog substituted with a phthalimide chromophore (Tb-III-DOTA-calix[4] arene-3OPr-OPhth). We show that, given its four aromatic rings, the calix[4] arene core acts as an effective sensitizer of Tb-centered luminescence. Substituents on the lower rim can modulate the aggregation behavior, which in turn determines the luminescence properties of the compounds. In solid state, the quantum yield of the phthalimide derivative is almost three times as high as that of the propyl-functionalized analog demonstrating a beneficial role of the chromophore on Tb-luminescence. In solution, however, the effect of the phthalimide group vanishes, which we attribute to the large distance between the chromophore and the lanthanide, situated on the opposite rims of the calix[4] arene. Both quantum yields and luminescence lifetimes show clear concentration dependence in solution, related to the strong impact of aggregation on the luminescence behavior. We also evidence the variability in the values of the criticalmicelle concentration depending on the experimental technique. Such luminescent calix[4] arene platforms accommodating stable lanthanide complexes can be considered valuable building blocks for the design of dual MR/optical imaging probes.