Development of LIMK inhibitors

In collaboration with 3D modellers and medicinal chemists, we developped small molecules inhibiting LIMK kinase activity in order to elaborate new targeted therapies

In collaboration with preclinicians, we performed several preclinical assays on different mouse models:

• Amyotrophic Lateral Sclerosis (Collaboration Patrick Vourc’h Christian Andres, U1253, Tours)
• Osteosarcoma (Collaboration Franck Verrecchia, UMR1238, Nantes)
• NF1 (Collaboration Piotr Topilko, Mondor, Créteil)
• Glioblatoma (Collaboration Pierre-François Cartron, U982, Nantes)
• NF2 (Collaboration Cristina Fernandez-Valle, Florida)