LIM kinases, LIMK1 and LIMK2

• Serine/Threonine and Tyrosine kinases
• crucial role in cytoskeleton dynamics by regulating actin filament and microtubule remodelling
• involved in many physiological processes such as cell division, differentiation, migration, apoptosis, and neuronal plasticity
• overexpressed or overactivated in several pathologies such as cancers, neuronal diseases, Neurofibromatosis type I

Our research strategy:

• Basic science: further understand LIMK regulations, activities and functions
• Develop new inhibitors of LIMKs as potential future targeted therapies (in collaboration with 3D modellers, medicinal chemists and with clinicians