Nf1 and LIMK2
- We showed that Nf1 prevents LIMK2 activation by ROCK, thus interfering with its cytoskeleton remodelling function (Vallee et al., 2012)
- Cytoskeleton remodelling is crucial for many physiological functions such as cell division, differentiation and motility as well as neuronal plasticity
- LIMK2 dysfunction has been observed in NF1 patients
