Project CLIMB’IN

As part of the French Call for Proposals “Grand Défi Biomédicaments” CLIMB’IN, a collaborative R&D project, has obtained funding from BPI France to meet the societal challenge of producing new biotherapies and production tools.

CLIMB’IN aimed to develop an innovative process analytical technology (PAT) solution that addresses the issue of optimizing industrial cell culture systems, in USP (upstream process) and DSP (downstream process). This solution will allow CDMOs (Contract Development and Manufacturing Organization) to reduce their production times and costs and thus make therapeutic products accessible to the greatest number of patients.

This collaborative project was led out by the NMNS laboratory of the University of Tours / CNRS and involved the LRGP laboratory of the University of Lorraine / CNRS and 3 companies: ONDALYS, INDATECH – Chauvin Arnoux Group, and SERVIER pharmaceutical group.

This BPI France funding provided funds for research expenses, for scientific equipment putchasing and for hiring of around ten people in R&D, design and services.

It was successfully finiched in october 2024 and resulted in advances in both Raman PAT instrumentation (already on the market by INDATECH) and methodology (2 papers published in 2025).

Scientific publications

• M. Rubini et al., Microchemical J, 2025, vol. 218, p. 115583, doi: 10.1016/j.microc.2025.115583
• M. Rubini et al., Pharmaceutics, 2025, vol. 17, p. 473, doi: 10.3390/pharmaceutics17040473