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Accueil > Publications > Recherche par années > Années 1990 > 1992

Breton, P ; Petit, C ; Bousser, MT ; Monsigny, M ; Mayer, R ; Roche, AC

Secretion of macrophage cytotoxic factors induced by new desmuramyl acylpseudopeptide analogs of muramyl dipeptide

Oncology Research 4 (3) 103-107

par Administrateur - publié le

Abstract :

Sixteen desmuramyl analogs of muramyl dipeptide (MDP) were tested for their abilities to stimulate cytotoxic factor secretion by mouse peritoneal macrophages. Among them, the pseudohexapeptide Boc-Gly psi[CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)-NHEt]-NH2-appeared to be four times more effective than MDP. From this study, the D configuration of the pseudo-alanyl (or lactyl) residue appears to be essential for activity.