Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
Squaramides: From Receptors to Antimicrobials
Macrocycles, Cages and Liposome-based Cobalt and Iron Complexes as Magnetic Resonance Imaging Probes
By solving the atomic structure of the transcription factor Rho of Mycobacterium tuberculosis by cryoEM, researchers from CBM and CBS (Montpellier) have identified a mutation specifically responsible for resistance to bicyclomycin in this pathogen.
Chronic Kidney Diseases (CKD) are a growing scourge worldwide, particularly in less developed countries with intensive agriculture. Several risk factors have been identified, but an undetermined etiology (CKDu) remains which may be linked to pesticides.
Development of a conjugate vaccine against the COVID19: SOBERANA 02 and the prevention of COVID19 during the OMICRON wave
Overcoming general rules of coordination chemistry ? Via a perfect size-match, bispidine cages lead to record stability, and for the first time, selectivity for the complexation of manganese(II) versus zinc(II). They can provide safer and more biocompatible MRI contrast agents.
This award recognizes her outstanding role in the development and use of coordination complexes for medical imaging and radio diagnostics.
The encapsulation of drugs into liposomes allows their activation only once they are released from the nanocargo. The in vivo follow-up of this processes is still a challenge, for which chemists and biologists of CBM propose a new strategy.
A chemo-enzymatic approach to ligation on a solid support