UPR 4301

Center for Molecular Biophysics, CNRS - Orleans

The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.

July 1, 2022 - Seminar of Dr. Julie Menetrey

"Molecular characterization of the versatile motor-cargo adaptors JIP3" Dr Julie Menetrey, Institute for Integrative Biology of the Cell,CEA, CNRS, Univ. Paris‐Sud, Université Paris‐Saclay, Gif‐sur‐Yvette

June 24, 2022 - Seminar of Prof. Mariusz Kaczmarek

"The tumor microenvironment disarms immune response and enhances the dark side of cancer". Pr Mariusz Kaczmarek, Chair of Medical Biotechnology, Dept. of Cancer Immunology Poznan University of Medical Sciences

A new mechanism of antiobiotic resistance

By solving the atomic structure of the transcription factor Rho of Mycobacterium tuberculosis by cryoEM, researchers from CBM and CBS (Montpellier) have identified a mutation specifically responsible for resistance to bicyclomycin in this pathogen.

The first molecules which really prefer manganese(II) over zinc(II)

Overcoming general rules of coordination chemistry ? Via a perfect size-match, bispidine cages lead to record stability, and for the first time, selectivity for the complexation of manganese(II) versus zinc(II). They can provide safer and more biocompatible MRI contrast agents.

A new luminescence for the direct follow-up of drug delivery

The encapsulation of drugs into liposomes allows their activation only once they are released from the nanocargo. The in vivo follow-up of this processes is still a challenge, for which chemists and biologists of CBM propose a new strategy.