UPR 4301
Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
News
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May 24th 2022 - Seminar from Dr Robert B. P. Elmes
Squaramides: From Receptors to Antimicrobials
May 20th 2022 - Seminar from Pr Janet Morrow
Macrocycles, Cages and Liposome-based Cobalt and Iron Complexes as Magnetic Resonance Imaging Probes
A new mechanism of antiobiotic resistance
By solving the atomic structure of the transcription factor Rho of Mycobacterium tuberculosis by cryoEM, researchers from CBM and CBS (Montpellier) have identified a mutation specifically responsible for resistance to bicyclomycin in this pathogen.
J.-M. Bonmatin co-authored an article linking neonicotinoid insecticides to chronic kidney disease of undetermined etiology (CKDu)
Chronic Kidney Diseases (CKD) are a growing scourge worldwide, particularly in less developed countries with intensive agriculture. Several risk factors have been identified, but an undetermined etiology (CKDu) remains which may be linked to pesticides.
March 14, 2022 - Webinar by Dr. Vicente Verez-Bencomo
Development of a conjugate vaccine against the COVID19: SOBERANA 02
and the prevention of COVID19 during the OMICRON wave
The first molecules which really prefer manganese(II) over zinc(II)
Overcoming general rules of coordination chemistry ? Via a perfect size-match, bispidine cages lead to record stability, and for the first time, selectivity for the complexation of manganese(II) versus zinc(II). They can provide safer and more biocompatible MRI contrast agents.
Eva Jakab Toth, director of the CBM, received the 2020 Joseph-Achille Le Bel Grand Prix from the Société Chimique de France
This award recognizes her outstanding role in the development and use of coordination complexes for medical imaging and radio diagnostics.
A new luminescence for the direct follow-up of drug delivery
The encapsulation of drugs into liposomes allows their activation only once they are released from the nanocargo. The in vivo follow-up of this processes is still a challenge, for which chemists and biologists of CBM propose a new strategy.
New methodological breakthrough in total protein synthesis
A chemo-enzymatic approach to ligation on a solid support