Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
With two new "Marie Skłodowska-Curie postdoctoral fellowships" obtained, CBM chemists of the "Synthetic Proteins and Bioorthogonal Chemistry" and the vMetal Complexes and MRI" teams have a total of five of these prestigious European grants ongoing.
A novel imaging probe Gd-K enables successful MRI visualization of early stage 4T1 metastatic breast cancer tumors in mice, with 3-fold contrast enhancement compared to DOTAREM, the MRI clinical gold standard.
Her work “An efficient strategy to bioconjugate disulfide-containing peptides via thiol-maleimide chemistry while preserving their bridging pattern” was awarded at the “Chemical Biology Symposium 2024” conference organized by the Société Chimique de France.
"Biogenicity and preservation of trace metals in hot spring deposits: preparing for a Mars sample return mission"
The CBM researcher Marcin Suskiewicz published a comprehensive review article that proposes a unifying narrative about protein post-translational modifications (PTMs), including the history of PTM research, chemical and mechanistic principles, and evolution.
"L'Atelier de la donnée Centre Val de Loire" at the service of researchers in the region
Brain cancer: a model of glioma in adult Drosophila to better understand the development of gliomas and explore therapeutic avenues.
"Metal Complexes as Diagnostics and Therapeutics"
"Modélisation de spectres quasiélastiques de neutrons provenant de protéines en solution".