UPR 4301
Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
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July 1, 2022 - Seminar of Dr. Julie Menetrey
"Molecular characterization of the versatile motor-cargo adaptors JIP3" Dr Julie Menetrey, Institute for Integrative Biology of the Cell,CEA, CNRS, Univ. Paris‐Sud, Université Paris‐Saclay,
Gif‐sur‐Yvette
Mariano Gago prize awarded to the collaboration between the group of Eva Jakab Toth and the University of Coimbra, Portugal
The Academy of Sciences recognizes and encourages bilateral scientific cooperation by awarding prizes to pairs of Franco-Portuguese researchers.
June 24, 2022 - Seminar of Prof. Mariusz Kaczmarek
"The tumor microenvironment disarms immune response and enhances the dark side of cancer". Pr Mariusz Kaczmarek, Chair of Medical Biotechnology, Dept. of Cancer Immunology Poznan University of Medical Sciences
A new mechanism of antiobiotic resistance
By solving the atomic structure of the transcription factor Rho of Mycobacterium tuberculosis by cryoEM, researchers from CBM and CBS (Montpellier) have identified a mutation specifically responsible for resistance to bicyclomycin in this pathogen.
J.-M. Bonmatin co-authored an article linking neonicotinoid insecticides to chronic kidney disease of undetermined etiology (CKDu)
Chronic Kidney Diseases (CKD) are a growing scourge worldwide, particularly in less developed countries with intensive agriculture. Several risk factors have been identified, but an undetermined etiology (CKDu) remains which may be linked to pesticides.
The first molecules which really prefer manganese(II) over zinc(II)
Overcoming general rules of coordination chemistry ? Via a perfect size-match, bispidine cages lead to record stability, and for the first time, selectivity for the complexation of manganese(II) versus zinc(II). They can provide safer and more biocompatible MRI contrast agents.
Eva Jakab Toth, director of the CBM, received the 2020 Joseph-Achille Le Bel Grand Prix from the Société Chimique de France
This award recognizes her outstanding role in the development and use of coordination complexes for medical imaging and radio diagnostics.
A new luminescence for the direct follow-up of drug delivery
The encapsulation of drugs into liposomes allows their activation only once they are released from the nanocargo. The in vivo follow-up of this processes is still a challenge, for which chemists and biologists of CBM propose a new strategy.
New methodological breakthrough in total protein synthesis
A chemo-enzymatic approach to ligation on a solid support