UPR 4301
Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
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Unveiling billion-year old life forms with X-ray vision
Synchrotron-based studies reveal unprecedented details of some of the most ancient traces of life in 3D. Fossilised bacteria 1.9 billion years old were imaged in situ in a fragment of rock by Ptychographic X-rays Computed Tomography documenting details of preservation not previously observed.
Manganese: A double agent for imaging ?
Manganese is a biocompatible metal ion, with great interest for MRI and PET. The alliance between Mn2+ and a bispidine ligand leads to an unprecedented kinetic inertness, which might enable its in vivo use without any toxicity risk.
Metallomics in geological time: trace element biosignatures evidence the influence of ocean chemistry on Earth’s earliest ecosystems
A new way of looking at ancient life: using trace element distributions co-located with biological carbonaceous materials in some of Earth’s oldest rocks
Numerical simulation to better select drugs before clinical trials
How to select drugs even before clinical trials?
Antimicrobial peptides: an atypical double-domain avian defensin, specifically found in eggs, reveals multiple roles in protection of the embryo
Increased biological potency of the double-domain AvBD11 compared to single-domain defensins highlighted by multidisciplinary collaborations based on peptide chemistry, NMR and biology.
Antimicrobial peptides: How peptide chemistry and NMR shed light on the antimicrobial activity of big defensins
The ancestral N-terminal hydrophobic domain of oyster big defensins drives bacterially triggered assembly into antimicrobial nanonets