Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
Synchrotron-based studies reveal unprecedented details of some of the most ancient traces of life in 3D. Fossilised bacteria 1.9 billion years old were imaged in situ in a fragment of rock by Ptychographic X-rays Computed Tomography documenting details of preservation not previously observed.
Manganese is a biocompatible metal ion, with great interest for MRI and PET. The alliance between Mn2+ and a bispidine ligand leads to an unprecedented kinetic inertness, which might enable its in vivo use without any toxicity risk.
A new way of looking at ancient life: using trace element distributions co-located with biological carbonaceous materials in some of Earth’s oldest rocks
How to select drugs even before clinical trials?
Increased biological potency of the double-domain AvBD11 compared to single-domain defensins highlighted by multidisciplinary collaborations based on peptide chemistry, NMR and biology.
The ancestral N-terminal hydrophobic domain of oyster big defensins drives bacterially triggered assembly into antimicrobial nanonets