UPR 4301

Center for Molecular Biophysics, CNRS - Orleans

The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.

Enzymatic detection in near infrared optical imaging and MRI with a single ligand complexed to different lanthanide ions

Applying a single molecular probe to monitor biomarkers in multiple, complementary imaging modalities is highly desirable to ascertain detection and to avoid the complexity associated with the use of agents of different chemical entities. We demonstrate the versatility of lanthanide complexes with respect to their potential for enzymatic detection in NIR luminescence, CEST and T1 MR imaging, controlled by the nature of the Ln3+ ion.

Marie Curie Postdoctoral Fellowships

With two new "Marie Skłodowska-Curie postdoctoral fellowships" obtained, CBM chemists of the "Synthetic Proteins and Bioorthogonal Chemistry" and the vMetal Complexes and MRI" teams have a total of five of these prestigious European grants ongoing.

Congratulations to Lylia Azoug for her poster prize!

Her work “An efficient strategy to bioconjugate disulfide-containing peptides via thiol-maleimide chemistry while preserving their bridging pattern” was awarded at the “Chemical Biology Symposium 2024” conference organized by the Société Chimique de France.

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