UPR 4301
Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
News
All news2024, March 22 - Seminar of Marie Catherine Sforna
Metals as tracers of biological processes and metabolisms on the early Earth and Mars
The study of terrestrial fossils in ancient rocks: a crucial approach to identify potential signs of life on Mars
The identification of distinctive signatures indicating the presence of past life in terrestrial sediments dating back billions of years could serve as a model for the search for traces of life in Martian rocks to be brought back to Earth by 2035.
Enzymatic detection in near infrared optical imaging and MRI with a single ligand complexed to different lanthanide ions
Applying a single molecular probe to monitor biomarkers in multiple, complementary imaging modalities is highly desirable to ascertain detection and to avoid the complexity associated with the use of agents of different chemical entities. We demonstrate the versatility of lanthanide complexes with respect to their potential for enzymatic detection in NIR luminescence, CEST and T1 MR imaging, controlled by the nature of the Ln3+ ion.
2024, March 15 - Seminar of Timothée Lathion
"Functionalized Near-Infrared Emitting Lanthanide(III)/Gallium(III) Metallacrowns with Red-Shifted Excitation"
Marie Curie Postdoctoral Fellowships
With two new "Marie Skłodowska-Curie postdoctoral fellowships" obtained, CBM chemists of the "Synthetic Proteins and Bioorthogonal Chemistry" and the vMetal Complexes and MRI" teams have a total of five of these prestigious European grants ongoing.
A novel MRI imaging probe targeted to Netrin-1, an emergent metastatic breast cancer biomarker
A novel imaging probe Gd-K enables successful MRI visualization of early stage 4T1 metastatic breast cancer tumors in mice, with 3-fold contrast enhancement compared to DOTAREM, the MRI clinical gold standard.
Congratulations to Lylia Azoug for her poster prize!
Her work “An efficient strategy to bioconjugate disulfide-containing peptides via thiol-maleimide chemistry while preserving their bridging pattern” was awarded at the “Chemical Biology Symposium 2024” conference organized by the Société Chimique de France.
2024, February 2 - Seminar of professor Michael ROWE
"Biogenicity and preservation of trace metals in hot spring deposits: preparing for a Mars sample return mission"
Comprehensive review about the “logic of protein modifications”
The CBM researcher Marcin Suskiewicz published a comprehensive review article that proposes a unifying narrative about protein post-translational modifications (PTMs), including the history of PTM research, chemical and mechanistic principles, and evolution.
Prochains évènements
Retour à l'agenda22 March 2024
2024, March 22 - Seminar of Marie Catherine Sforna
Metals as tracers of biological processes and metabolisms on the Early Earth & Mars