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Accueil > Publications > Recherche par années > Années 1990 > 1993

Guis, C ; Bruetschy, L ; Meudal, H ; Roques, BP ; Gacel, GA

Investigation of the structural parameters involved in the delsta-opioid selectivity of several families of familes opioid-peptides

International Journal of Peptide and Protein Research 41 (6) 576-586

par Administrateur - publié le , mis à jour le

Abstract :

Three series of highly d-opioid selective peptides are now available, and each family is used as template to investigate the structural parameters involved in d-receptor recognition and in the modulation of the selectivity of the parent peptide. The first series includes cyclic derivatives such as Tyr-D-Pen-Gly-Phe-D-Pen(DPDPE) and Tyr-D-Pen-Gly-Phe-Pen(DPLPE) ; the second are the synthetic linear constrained peptides [Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(DSTBULET), Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(OtBu) (BUBU) and especially Tyr-D-CyS(StBu)-Gly-Phe-Leu-Thr(OtBu) (BUBUC)] and the last one the natural peptides [Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2(deltorphin or dermenkephalin)and Tyr-D-Ala-Phe-Asp-Val-Val-GlyNH2 ([D-Ala2] deltorphin 1)].