Accueil > Publications > Recherche par années > Années 1990 > 1994

Monsigny, M ; Roche, AC ; Midoux, P ; Mayer, R

Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes

Advanced Drug Delivery Reviews 14 (1) 1-24

par Administrateur - publié le

Abstract :

Cell surface receptors are good candidates to selectively target drugs, oligonucleotides or even genes by making use of their specific ligands. A large number of mammalian cells express cell surface sugar-binding proteins, also called ’’membrane lectins’’. Therefore, sugars may be used as specific recognition signals to specifically deliver biological active components. Tens of membrane lectins with different sugar specificities have been characterized ; some of them actively carry their ligands to intracellular compartments, including endosomes, lysosomes and, in some cases, Golgi apparatus.