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Accueil > Publications > Recherche par années > Années 1990 > 1994

Sadatsowti, B ; Debre, P ; Mollet, L ; Quint, L ; Hadida, F ; Leblond, V ; Bismuth, G ; Autran, B

An inhibitor of cytotoxic functions produced by cd8(+)cd57(+) t-lymphocytes from patients suffering from aids and immunosuppressed bone-marrow recipients

European Journal of Immunology 24 (11) 2882-2888

par Administrateur - publié le

Abstract :

An inhibitor of the cytotoxic functions (ICF) mediated by human immunodeficiency virus (HIV)- or HLA-specific cytotoxic T lymphocytes, natural killer and lymphokine-activated killer (LAK) cells is secreted by CD8(+)CD57(+) T lymphocytes, a subset expanded during infection with HIV and after bone marrow transplantation. We previously showed an apparent molecular mass of 20-30 kDa for this soluble glycosylated concanavalin A-binding inhibitor which is distinct from known cytokines. Here, we report a characterization of the mechanism of action of this CD8(+)CD57(+) ICF. We show that the ICF-induced inhibition of LAK cell cytolytic activity is transient, with a spontaneous recovery of cytolytic potential after 18 h.