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Truffert, JC ; Asseline, U ; Thuong, NT ; Brack, A

Synthesis, characterization and binding properties of peptide oligonucleotide conjugates containing the SPKK peptide motif

Protein and Peptide Letters 2 (3) 419-424

par Administrateur - publié le

Abstract :

Peptide-oligonucleotide hybrid molecules 6 and 7 have been synthesized by on-line solid phase synthesis using allyloxycarbonyl (Alloc) side chain protection for serine. The conjugates have been characterized by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The interaction of conjugates 6 and 7 with a complementary sequence has been studied by absorption spectroscopy.