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Spach, C ; Lucchiari, N ; Bureaud, N ; Motta, R

Fully and long-term xenogeneic hematopoietic chimeras created in poorly concordant rat-mouse combinations - expression of hereditary donor characteristics

Experimental Hematology 23 (11) 1192-1203

par Administrateur - publié le

Abstract :

We created fully and stable xenogeneic hematopoietic chimeras in ’’poorly concordant’’ rat-mouse strain combinations defined by their high histocompatibility-antigen disparity and by the high titer of mouse-serum natural cytotoxic antibodies (NcAb) to rat donor bone marrow cells (BMC). Recipients were adult male (C57BL/6 x DBA/2)F-1 (BDF1) mice, and donors of untreated BMC were adult male WAG strain rats.