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Accueil > Publications > Recherche par années > Années 1990 > 1997

Pichon, C ; Freulon, I ; Midoux, P ; Mayer, R ; Monsigny, M ; Roche, AC

Cytosolic and nuclear delivery of oligonucleotides mediated by an amphiphilic anionic peptide

Antisense & Nucleic Acid Drug Development 7 (4) 335-343

par Administrateur - publié le

Abstract :

Antisense oligonucleotides (ODN) were easily introduced into the cytosol of mammalian cells on permeabilization of the plasma membrane by an amphiphilic anionic peptide. The E5CA peptide (GLFEAIAEFIEGG-WEGLIEGCA) is an E5 peptide analog derived from the N-terminal segment of the HA2 subunit of influenza virus hemagglutinin.