Accueil > Publications > Recherche par années > Années 1990 > 1998

Bellier, B ; Da Nascimento, S ; Meudal, H ; Gincel, E ; Roques, BP ; Garbay, C

Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid

Bioorganic & Medicinal Chemistry Letters 8 (11) 1419-1424

par Administrateur - publié le

Abstract :

A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists. (C) 1998 Elsevier Science Ltd. All rights reserved.