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Bressanelli, S ; Tomei, L ; Roussel, A ; Incitti, I ; Vitale, RL ; Mathieu, M ; De Francesco, R ; Rey, FA

The RNA-dependent RNA polymerase of hepatitis C virus : 3D structure and implications for viral replication

Acta Crystallographica Section D-Biological Crystallography 56 Suppl.76

par Administrateur - publié le

Abstract :

We report the crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus, a major human pathogen, to 2.8-Å resolution. This enzyme is a key target for developing specific antiviral therapy. The structure of the catalytic domain contains 531 residues folded in the characteristic fingers, palm, and thumb subdomains. The fingers subdomain contains a region, the "fingertips," that shares the same fold with reverse transcriptases. Superposition to the available structures of the latter shows that residues from the palm and fingertips are structurally equivalent.