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Thierry, J ; Grillon, C ; Gaudron, S ; Potier, P ; Riches, A ; Wdzieczak-Bakala, J

Synthesis and biological evaluation of analogues of the tetrapeptide N-Acetyl-Ser-Asp-Lys-Pro (AcSDKP), an inhibitor of primitive haematopoietic cell proliferation

Journal of Peptide Science 7 (5) 284-293

par Administrateur - publié le

Abstract :

The tetrapeptide IV-Acetyl-Ser-Asp-Lys-Pro (AcSDKP), an inhibitor of hacmatopoletic stem cell proliferation, reduces in vivo and in vitro the damage to the stein cell compartment resulting from treatment with chemotherapeutic agents or ionizing radiations. In order to provide new molecules likely to improve the myeloprotection displayed by this tetrapeptide, we have prepared a set of analogues of AcSDKP. These compounds are derived from the parent peptide by substitution or modification of the N- or of the C-terminus, or substitution of side chains.